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SPH Biorepository  Collaborators  University of California, Berkeley University of California, San Francisco Children's Hospital Research Institute               Considering the high cost and effort invested in epidemiological studies, it is crucial to make provisions for upcoming biomarker studies, and minimize future research cost by maximizing information obtained from banked samples. Tens of thousands of various biological samples have been stored and archived through the CHAMACOS and Ozone Projects. The Laboratory Cores of the CHAMACOS and Superfuend centers (Dr.Holland is a Director of both Cores) have accumulated substantial expertise in the development of customized databases to barcode and monitor samples location, transfer, and use. Based on the successful experience of these Laboratory Cores, a new School of Public Health Biorepository was established in 2004.     The main advantage of SPH Biorepository is to create a centralized facility for many research programs, as well as for new ones; more effective use of the available storage space; development of new database management tools; and quality control of sample processing and banking. While maintaining ultimate control of the samples accumulated in their research projects, PIs will have the assurance of competent handling of their biological samples, reliable access, safe storage, and expert advice from the Biorepository personnel. In the long-term, the Biorepository will provide: Safe and orderly storage of banked samples Samples diversification in case of a major disaster Leverage for additional funding for the new projects  Publications & Presentations  Aamodt RL, Anouna A, Baird P, Beck JC, Bledsoe MJ, De Souza Y, Grizzle WE, Gosh J, Holland NT, Hakimian R, Michels C, Pitt KE, Sexton KC, Shea K, Stark A, Vaught J. Best Practices for Repositories I:Collection, Storage, and Retrieval of Human Biological Materials for Research. International Society for Biological and Environmental Repositories (ISBER), Cell Preservation Technology V 3, N 1: 1-49, 2005. Holland NT, Pfleger LP, Berger E, Ho A, Bastaki M. Molecular Epidemiology Biomarkers - Sample Collection and Banking Considerations. Toxicology and Applied Pharmacology, 206:261-68, 2005. Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, et al. 2005. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environ Health Perspect 113(10):1419-1429. Brenda Eskenazi, Asa Bradman, Eleanor Gladstone, Selene Jaramillo, Kelly Birch, Nina Holland, "CHAMACOS, A Longitudinal Birth Cohort Study: Lessons from the Fields", J.of Children's Health, 1, 3-27, 2003. Nina T. Holland, Martyn T. Smith, Brenda Eskenazi, Maria Bastaki. "Biological sample collecion and processing for molecular epidemiological studies." Mutation Research Reviews, 534, 217-34, 2003.