Karen Huen, Kim Harley, Jordan Brooks, Alan Hubbard, Asa Bradman, Brenda Eskenazi, Nina Holland, Developmental Changes in PON1 Enzyme Activity in Young Children and Effects of PON1 Polymorphisms, Environmental Health Perspectives (2009), doi: 10.1289/ehp.0900870

Philip Thomas, Nina Holland, Claudia Bolognesi, Micheline Kirsch-Volders, Stefano Bonassi, Errol Zeiger,
Siegfried Knasmueller, Michael Fenech, Buccal micronucleus cytome assay, Nature Protocols (2009),doi:10.1038/nprot.2009.53

Stefano Bonassi, Barbara Biasotti, Micheline Kirsch-Volders, Siegfried Knasmueller, Errol Zeiger, Sema Burgaz, Claudia Bolognesi, Nina Holland, Philip Thomas and Michael Fenech on behalf of the HUMNXL Project Consortium, State of the art survey of the buccal micronucleus assay- a first stage in the HUMN project initiative, Mutagenesis (2009), doi:10.1093/mutage/gep019

Chen C, Arjomandi M, Tager IB, Holland N, Balmes JR. Effects of antioxidant enzyme polymorphisms on ozone induced lung function changes. Eur Respir J (2007); 30: 677–683 DOI: 10.1183/09031936.00160806

Heyman MB, Garnett EA, Shaikh N, Huen K, Joe F, Harmatz P, Winter H, Baldassano R, Cohen S, Gold B, Kirschner B, Ferry G, Stege E, Holland N. Folate concentrations in pediatric patients with newly diagnosed inflammatory bowel disease. Am J Clin Nutr 2009;89:545–50.

Huen Karen, Richter Rebecca, Furlong Clement, Eskenazi Brenda, Holland Nina, Validation of PON1 enzyme activity assays for longitudinal studies, Clinica Chimica Acta (2008), doi: 10.1016/j.cca.2008.12.019

Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, Holland N, Fung EB, Schumacher L, Harmatz P. Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biology Med. (2008)

Harley K, Macher J, Lipsett M, Duramad P, Holland N, Prager S, Ferber J, Bradman A, Eskenazi B, Tager I. Fungi and pollen exposure in the first months of life and risk of early childhood wheezing. Thorax. (2008).

Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, Zeiger E, Knasmueller S, Fenech M. The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: The HUMN project perspective on current status and knowledge gaps. Muta. Res.:Rev Muta. Res. (2008), doi:10.1016/j.mrrey.2008.03.007

Chevrier J, Eskenazi B, Holland N, Bradman A, Barr DB. Effects of exposure to polychlorinated biphenyls and organochloride pesticides on thyroid function during pregnancy. Am. J. Epidemiol. 168 (3): 298-310, 2008

Block G, Jensen CD, Morrow JD, Holland N, Norkus EP, Milne GL, Hudes M, Dalvi TB, Crawford PB, Fung EB, Schumacher L, Harmatz P. The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Free Radic Biol Med 2008, 45:377-384.

Vose S, Fujioka K, Gulevich A, Lin A, Holland N, Casida J. Cellular function of neuropathy target esterase in lysophosphatidylcholine action. Toxicol. Appl. Pharmacol. (2008).

Holland N, Dong J, et al. Reduced Intracellular T-helper 1 Interferon-gamma in Blood of Newly-Diagnosed Children with Crohn's Disease and Age-related Changes in Th1/Th2 cytokine profiles. Pediatr Res. 2008 Mar; 63(3): 257-62..

Arjomandi, M., Tager, et al (2008). "Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone." JOEM 50(3): 341-9.

Eskenazi B, Rosas L, et al (2008). "Pesticide Toxicity and the Developing Brain." Nordic Pharmacological Society 102: 228-236.

P. Duramad, I. Tager, N. Holland. Cytokines and other immunological biomarkers in children's environmental health studies. Toxicology Letters. Toxicol Lett. 2007 Jul 30, 172(1-2): 48-59. Epub 2007 May 25.

Vose S, Holland N, Eskenazi N, Casida J. Lysophosphatidylcholine Hydrolases of Human Erythrocytes, Lymphocyes and Brain: Sensitive Targets of Conserved Specificity for Organophosphorus Delayed Neurotoxicant. Toxicology and Applied Pharmacology (2007), doi: 10.1016/j.taap.2007.06.008

Chen C, Arjomandi M, et al (2007). "Effects of Chronic and Acute Ozone Exposure on Lipid Peroxidation and Antioxidant Capacity in Healthy Young Adults." Environmental Health Perspective. 11 Sep 2007.

Bonassi S, Znaor A, Ceppi M, Lando C, Chang W P, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti P, Bolognesi C, Cebulska-Wasilewska A, Fabianova E, Fucic A, Hagmar L, Joksic G, Martelli A, Migliore L, Mirkova E, Scarfi M, Zijno A, Norppa H, Fenech M. An Increased Micronucleus Frequency in Peripheral Blood Lypthocytes Predicts the Risks of Cancer in Humans. Carcinogenesis, 28: 625-631,2007.

Holland N, Golden D, Hubbard A, Chen C, Huen K, Harmatz P, Heyman MB. Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with Inflammatory Bowel Disease. Pediatric Research, submitted, 2007.

Michael Fenech, Nina Holland, Siegfried Knasmueller, Sema Burgaz and Stefano Bonassi. Report on the Buccal Micronucleus Assay Workshop organised by the  International Human Micronucleus  (HUMN) Project – Antalya Turkey 2007

Bradman A, Schwartz J, Fenster L, Barr D, Holland N, Eskenazi B. Factor predicting organochlorine pesticide level in pregman Latina women living in a United States agriculture area. Journal of Exposure Science and Environmental Epidermiology (2006), 1-12.

Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, Balmes JR, Tager IB, Holland NT. Genotype-activity relationship for Mn-superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase in humans, Pharmacogenetics and Genomics, 16:279-286, 2006.

Chen C, Arjomandi M, Qin H, Balmes J, Tager I, Holland NT. Cytogenetic Damage in Buccal Epithelia and Peripheral Lymphocytes in Young Healthy Individuals Exposed to Ozone, Mutagenesis, 21:131-137, 2006

Duramad P, Tager I, Eskenazi B, Holland NT. Expression of Th1/Th2 cytokines in human blood after in vitro treatment with chlorpyrifos, and its metabolites, in combination with endotoxin LPS and allergen Der p1, Journal of Applied Toxicology, 26(5):458-65, 2006.

P.Duramad, K.Harley, M.Lipsett, A.Bradman, B.Eskenazi, N.Holland, I.Tager Early environmental exposures and intracellular Th1/Th2 cytokine profiles in 24-month old children living in an agricultural area, Environmental Health Perspectives, v.14, 12:1916-1922, 2006.

Furlong C*, Holland NT*, Richter R, Bradman A, Ho A, Eskenazi B. PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity, Pharmacogenetics and Genomics, 16:183-190, 2006.
* = first co-authors

Holland NT, Furlong C, Bastaki M, Richter R, Bradman A, Ho A, Beckman K, Eskenazi B. Paraoxonase polymorphisms, haplotypes and enzyme activity in Latino mothers and newborns, Environmental Health Perspectives, 114:985–991, 2006.

Holland N, Golden D, Hubbard A, Chen C, Huen K, Harmatz P, Heyman MB. Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with Inflammatory Bowel Disease. Pediatric Research, 61(2):209-14, 2006.

Huen K, Gunn L, Duramad P, Jeng M, Scalf R, Holland NT. Application of a Geographic Information System to Explore Associations Between Air Pollution and Cytogenetic Damage in African-American Children and Adults. Environmental Molecular Mutagenesis, 47:236-246, 2006.

Kirsch-Volders M, Tremp A, Bonassi S, Roelants M, Holland NT, Chang WP, Zeiger E, Aka P, Godderis L, Ishikawa H, Laffon B, Leopardi P, Lucero L, Mateuca R, Migliore L, Norppa H, Pitarque M, Teixeira JP, Fenech M. XRCC1, GSTM1 and EPHX1 Polymorphisms are predictive for micronucleus frequencies in human populations: results from a pooled analysis of data from the human micronucleus (HUMN) project, Cancer Biomarkers and Prevention, 15(5):1038-42, 2006.

Neri M, Ugolini D, Bonassi S, Fucic A, Holland NT, Knudsen LE, Sram RJ, Ceppi M, Bocchini V, Merlo DF.Children’s exposure to environmental pollutants and biomarkers of genetic damage: I Overview and critical issues. Mutation Research Reviews, 612:1-13, 2006.

Neri M, Ugolini D, Bonassi S, Fucic A, Holland NT, Knudsen LE, Sram RJ, Ceppi M, Bocchini V, Merlo DF. Children’s exposure to environmental pollutants and biomarkers of genetic damage: II. Results of a comprehensive literature search, Mutation Research Reviews, 612:14-39, 2006.

Tujague J, Bastaki M, Holland NT, Balmes J, Tager I, "Antioxidant intake, GSTM1 polymorphism and pulmonary function in healthy young adults, European Respiratory Journal, 27:282-288, 2006.

Aamodt RL, Anouna A, Baird P, Beck JC, Bledsoe MJ, De Souza Y, Grizzle WE, Gosh J, Holland NT, Hakimian R, Michels C, Pitt KE, Sexton KC, Shea K, Stark A, Vaught J. Best Practices for Repositories I:Collection, Storage, and Retrieval of Human Biological Materials for Research. International Society for Biological and Environmental Repositories (ISBER), Cell Preservation Technology V 3, N 1: 1-49, 2005.

Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, Balmes J, Tager I, Holland NT. Genotype-activity relationship for Mn-superoxide dismutase (MnSOD), glutathione peroxidase 1 (GPX1) and catalase in humans, Pharmacogenetics and Genomics, 16(4):279-86, 2005.

Quistad GB, Fisher KJ, Owen SC, Klintenberg R, Casida JE. 2005. Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates. Toxicol Appl Pharmacol 205(2):149-156

Bradman A, Eskenazi B, Barr DB, Bravo R, Castorina R, Chevrier J, Kogut K, Holland NT, Harnly ME, McKone TE. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community, Environmental Health Perspectives, 113(12):1802-7, 2005.

Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodological Issues in Conducting Longitudinal Birth Cohort Studies: Lessons Learned from the Centers for Children’s Environmental Health and Disease Prevention Research, Environmental Health Perspectives, 113: 1419-1429, 2005.

Tager, I. B., J. Balmes, et al. (2005). "Chronic exposure to ambient ozone and lung function in young adults." Epidemiology 16(6): 751-9.

Holland NT, Pfleger LP, Berger E, Ho A, Bastaki M. Molecular Epidemiology Biomarkers - Sample Collection and Banking Considerations. Toxicology and Applied Pharmacology, 206:261-68, 2005.

Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT. Association between in utero organophosphate pesticide exposure and neurobehavioral functions in neonates, NeuroToxicology, 26:199-209, 2005.

Duramad P, Hubbard A, McMahon C, Holland NT, Flow cytometric detection of intracellular Th1/Th2 cytokines using whole blood: Biomarker validation for use in epidemiological studies”, Cancer Epidemiology Biomarkers&Prevention, 13(9): 1452-8, 2004.

Duramad P, McMahon CW, Hubbard A, Eskenazi B, Holland NT. Flow cytometric detection of intracellular TH1/TH2 cytokines using whole blood: validation of immunologic biomarker for use in epidemiologic studies. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1452-8.

Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell N, Barr D, Furlong C, Holland NT, “Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population”, Environmental Health Perspectives, 12: 1-9, 2004.

M.Fenech, WP Chang, M.Kirsch-Volders, N.Holland, S.Bonassi, E.Zeiger “HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures”, MutationResearch, 534: 65-75, 2003.

M.Fenech, S.Bonassi, J.Turner, M.Ceppi, W.P. Chang, N.Holland et al.”Intra- and interlaboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring  exercise by the HUMN project” Mutation Research, 534/1-2: 45-64, 2003.

Eskenazi B, Bradman A, Gladstone EA, Jaramillo S, Birch K, Holland NT, "CHAMACOS, A Longitudinal Birth Cohort Study: Lessons from the Fields", J.of Children's Health, 1, 3-27, 2003.

Holland NT, Smith MT, Eskenazi B, Bastaki M. "Biological sample collecion and processing for molecular epidemiological studies", Mutation Research Reviews, 534, 217-34, 2003.

Laura Gunn, Matthew S. Forrest, Luoping Zhang, Nina T. Holland and Martyn T. Smith. "Biomarkers of early effect in the study of cancer risk." Book Chapter, "Biomarkers of Environmentally Associated Disease: Technologies, Concepts and Perspectives" with eds. Wilson, SH and Suk, WA., 2002.

Holland NT, Zhang L, Smith MT. "Cytogenetic biomarkers and air pollution. In: Relationship between acute and chronic effects of air pollution", ed. U. Heinrich & U.Mohr, ILSI press, Washington, D.C., pp.65-78, 2000.

Kunzli, N., F. Lurmann, et al. (1997). "Association between lifetime ambient ozone exposure and pulmonary function in college freshmen--results of a pilot study." Environ Res 72(1): 8-23.