Stephen M. Rappaport
Professor of Environmental Health
Chair, EHS Graduate Group
Ph.D., University of North Carolina at Chapel Hill, 1974
759 University Hall
School of Public Health
University of California
50 University Hall #7360
Berkeley, CA 94720-7360
B.S., University of Illinois, Chemistry, 1969
M.S.P.H., University of North Carolina at Chapel Hill, Air and Industrial Hygiene, 1973
Ph.D., University of North Carolina at Chapel Hill, Air and Industrial Hygiene, 1974
PH150B Introduction to Environmental Health Sciences
Professor Rappaport is Director and Principal Investigator of the Berkeley Center for Exposure Biology, a multidisciplinary program that brings together Berkeley researchers from Public Health, Chemistry, and Electrical Engineering to develop a new generation of biomarkers and biosensors for environmental epidemiology. He is a pioneer in the emerging field of ‘Exposure Biology’ and a prominent advocate of the concept of the ‘Exposome’ as a new paradigm for environmental health. Much of his current research involves the development and application of blood protein adducts as biomarkers of exposure to toxic chemicals arising from inhalation, ingestion, and endogenous processes. This has led to the concept of the protein adductome, representing signatures of people’s exposures to toxic chemicals. By comparing adductomes across populations, Prof. Rappaport hopes to identify important biomarkers of chronic diseases. He has also used environmental measurements and biomarkers to elucidate the human metabolism of several toxic chemicals, notably benzene, and to quantify interindividual variability in biomarker levels due to genetic, environmental and lifestyle factors. Prof. Rappaport has also published extensively in areas related to the assessment of long-term chemical exposures for purposes of controlling hazards and of investigating exposure-response relationships. He has more than 200 peer-reviewed publications and has collaborated extensively with investigators throughout the world.
- T. Whitehead, C. Metayer, M.H. Ward, M.G. Nishioka, R. Gunier, J.S. Colt, P. Reynolds, S. Selvin, P. Buffler, and S.M. Rappaport. Is house-dust nicotine a good surrogate for household smoking? Am J Epidemiol, 169(9):1113-23 (2009).
- S.M. Rappaport, Implications of the Exposome for Exposure Science, J Exposure Sci Environ Epidemiol, 21: 5-9 (2011).
- H. Li, H. Grigoryan, W. E. Funk, S. S. Lu, S. Rose, E. R. Williams, and S.M. Rappaport, Profiling Cys34 Adducts of Human Serum Albumin by Fixed-Step Selected Reaction Monitoring, Mol Cell Proteomics, 10(3):M110.004606 (2011).
- S. Liu, S. K. Hammond, and S.M. Rappaport, Statistical Modeling to Determine Sources of Variability in Exposures to Welding Fumes, Ann Occup Hyg, 55(3):305-18 (2011).
- S.M. Rappaport, H. Li, H. Grigoryan, W.E. Funk, and E.R. Williams, Adductomics: Characterizing Exposures to Reactive Electrophiles, Toxicol Letters, 13;213(1):83-90 (2012).
- S. M. Rappaport, Discovering Environmental Causes of Disease, J Epidemiol Comm Health, 66: 99-102 (2012).
- H. Grigoryan, H. Li, A.T. Iavarone, E.R. Williams and S.M. Rappaport, Cys34 Adducts of Reactive Oxygen Species in Human Serum Albumin, Chem Res Toxicol, 25(8):1633-42 (2012).
- S.M. Rappaport, Biomarkers Intersect with the Exposome, Biomarkers, 17(6):483-9 (2012)
- S.M. Rappaport, S. Kim, R. Thomas, B.A. Johnson, F.Y. Bois and L.L Kupper, Low-dose Metabolism of Benzene in Humans: Science and Obfuscation, Carcinogenesis, 34(1): 2-9 (2013).