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PH150B Introduction to Environmental Health Sciences
 

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Professor Rappaport is Director and Principal Investigator of the Berkeley Center for Exposure Biology, a multidisciplinary program that brings together Berkeley researchers from Public Health, Chemistry, and Electrical Engineering to develop a new generation of biomarkers and biosensors for environmental epidemiology. He is a pioneer in the emerging field of ‘Exposure Biology’ and a prominent advocate of the concept of the ‘Exposome’ as a new paradigm for environmental health.  Much of his current research involves the development and application of blood protein adducts as biomarkers of exposure to toxic chemicals arising from inhalation, ingestion, and endogenous processes.  This has led to the concept of the protein adductome, representing signatures of people’s exposures to toxic chemicals.  By comparing adductomes across populations, Prof. Rappaport hopes to identify important biomarkers of chronic diseases.  He has also used environmental measurements and biomarkers to elucidate the human metabolism of several toxic chemicals, notably benzene, and to quantify interindividual variability in biomarker levels due to genetic, environmental and lifestyle factors. Prof. Rappaport has also published extensively in areas related to the assessment of long-term chemical exposures for purposes of controlling hazards and of investigating exposure-response relationships. He has more than 200 peer-reviewed publications and has collaborated extensively with investigators throughout the world.

Director, Center for Exposure Biology