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PH 170B Toxicology (F) [description]
 
PH 270B Toxicology I (F) [description]
 
NUSCTX 11 Introduction to Toxicology (F) [description]
 

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Ongoing research projects include:

• Biomarkers of Carcinogenesis
• Diet as a Risk Factor for Cancer
• Biomarkers of Benzene Exposure and Genotoxicity
• Childhood Leukemia and Environmental Exposures
• Molecular Epidemiology of non-Hodgkin Lymphoma
• Studies of Environmental Mutagens and Carcinogens

Research in the Molecular Epidemiology and Toxicology laboratory aims to find the causes of blood cancers (leukemia & lymphoma) in adults and children and to develop new therapies for their treatment. To achieve this goal we are developing biomarkers that will allow identification of persons at risk of leukemia and lymphoma and are examining the effects of chemicals linked with these diseases, such as benzene, formaldehyde and chlorinated solvents, in molecular epidemiology studies of exposed human populations. Studies on the basic biology of these diseases in cell culture aim to understand the role of stem cells, chromosome changes, epigenetic changes, and immunological dysfunction in the development of these diseases and elucidate targets for potential therapy.
 

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Lin YS, Vermeulen R, Tsai CH, Waidyanatha S, Lan Q, Rothman N, Smith MT, Zhang L, Shen M, Li G, Yin S, Kim S, Rappaport SM (2007) Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers. Environ Health Perspect 115(1):28-34. [abstract]
 
Hartge P, Smith MT (2007) Environmental and behavioral factors and the risk of Non-Hodgkin Lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):367-8. [abstract]
 
Smith MT, Jones RM, Smith AH (2007) Benzene exposure and risk of Non-Hodgkin Lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):385-91. [abstract]
 
Hegedus CM, Skibola CF, Bracci P, Holly EA, Smith MT (2007) Screening the human serum proteome for genotype-phenotype associations: Ananalysis of the IL6 -174G>C polymorphism. Proteomics 7(4):548-557. [abstract]
 
McHale CM, Zhang L, Hubbard AE, Zhao X, Baccarelli A, Pesatori AC, Smith MT, Landi MT (2007) Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology 229(1-2):101-13. [abstract]
 
Rollinson S, Smith AG, Allan JM, Adamson PJ, Scott K, Skibola CF, Smith MT, Morgan GJ (2007) RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Leuk Res 31(2):169-74. [abstract]
 
See Martyn Smith's research group website for a full list of publications.