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PH 170B Toxicology (F) [description]
 
PH 270B Toxicology I (F) [description]
 
NUSCTX 11 Introduction to Toxicology (F) [description]
 

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Ongoing research projects include:

• Biomarkers of Carcinogenesis
• Diet as a Risk Factor for Cancer
• Biomarkers of Benzene Exposure and Genotoxicity
• Childhood Leukemia and Environmental Exposures
• Molecular Epidemiology of non-Hodgkin Lymphoma
• Studies of Environmental Mutagens and Carcinogens

Research in the Molecular Epidemiology and Toxicology laboratory aims to find the causes of blood cancers (leukemia & lymphoma) in adults and children and to develop new therapies for their treatment. To achieve this goal we are developing biomarkers that will allow identification of persons at risk of leukemia and lymphoma and are examining the effects of chemicals linked with these diseases, such as benzene, formaldehyde and chlorinated solvents, in molecular epidemiology studies of exposed human populations. Studies on the basic biology of these diseases in cell culture aim to understand the role of stem cells, chromosome changes, epigenetic changes, and immunological dysfunction in the development of these diseases and elucidate targets for potential therapy.
 

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Ren X, Lim S, Smith MT, Zhang L (2009) Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci. 107(2):367-75. PMID: 19064679.
 
Scelo, G, Metayer, C, Zhang L, Wiemels, JL, Aldrich MC, Selvin S, Month S, Smith MT, Buffler PA (2009) Household exposure to paint and petroleum solvents, chromosomal translocations and the risk of childhood leukemia. Environ Health Perspect. 117(1):133-9. PMID: 19165400.
 
Guyton KZ, Kyle AD, Aubrecht J, Cogliano VJ, Eastmond DA, Jackson M, Keshava N, Sandy MS, Sonawanee B, Zhang L, Waters MD, Smith MT (2009) Improving prediction of chemical carcinogenicity by considering mechanisms and applying toxicogenomic approaches. Mutat Res. 2009 Mar-Jun;681(2-3):230-40. PMID: 19010444.
 
Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit C, Loh M, Buffler P, Yeh RF (2008) Chromosome 12p deletions in TEL-AML 1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnataly. Cancer Res. Dec 1;68(23):9935-44. PMID: 19047175.
 
Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA (2008) NQO1 Polymorphisms and De Novo Childhood Leukemia: A HuGE Review and Meta-Analysis. Am J Epidemiol. Dec 1; 168(11):1221-32. PMID: 18945694.
 
McHale CM, Lan Q, Corso C, Li G, Zhang L, Vermeulen R, Curry JD, Shen M, Turakulov R, Higuchi R, Germer S, Yin S, Rothman N, Smith MT (2008) Chromosome translocations in workers exposed to benzene. J Natl Cancer Inst Monogr. (39):74-7. PMID: 18648008.
 
Lin YS, Vermeulen R, Tsai CH, Waidyanatha S, Lan Q, Rothman N, Smith MT, Zhang L, Shen M, Li G, Yin S, Kim S, Rappaport SM (2007) Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers. Environ Health Perspect 115(1):28-34. [abstract]
 
Hartge P, Smith MT (2007) Environmental and behavioral factors and the risk of Non-Hodgkin Lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):367-8. [abstract]
 
Smith MT, Jones RM, Smith AH (2007) Benzene exposure and risk of Non-Hodgkin Lymphoma. Cancer Epidemiol Biomarkers Prev 16(3):385-91. [abstract]
 
Hegedus CM, Skibola CF, Bracci P, Holly EA, Smith MT (2007) Screening the human serum proteome for genotype-phenotype associations: Ananalysis of the IL6 -174G>C polymorphism. Proteomics 7(4):548-557. [abstract]
 
McHale CM, Zhang L, Hubbard AE, Zhao X, Baccarelli A, Pesatori AC, Smith MT, Landi MT (2007) Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology 229(1-2):101-13. [abstract]
 
Rollinson S, Smith AG, Allan JM, Adamson PJ, Scott K, Skibola CF, Smith MT, Morgan GJ (2007) RAD51 homologous recombination repair gene haplotypes and risk of acute myeloid leukaemia. Leuk Res 31(2):169-74. [abstract]