Research interests:
- Mechanisms of bone marrow toxicity caused by benzene
- Application of FISH as a biomarker in studies of childhood leukemia and other types of cancer
- Application of gene expression profiling in molecular epidemiology and RNAi
Dr. Zhang has been working toward applying FISH to understand the mechanisms of bone marrow toxicity caused by benzene and as a biomarker for childhood leukeumia and other types of cancer. Recently, her research interest has turned to toxicogenomics, leading research efforts to apply gene expression profiling in molecular epidemiology and RNAi in human cell culture studies of chemical exposure.
Zhang L, Rothman N, Li G, Guo W, Yang W, Hubbard AE, Hayes RB, Yin S, Lu W, Smith MT. Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environmental Mol Mut. 2007. In press.
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McHale CM, Zhang L, Hubbard AE, Zhao X, Baccarelli A, Pesatori AC, Smith MT, Landi MT. Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects. Toxicology. 2007 Jan 5;229(1-2):101-13. PMID: 17101203
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Lin YS, Vermeulen R, Tsai CH, Waidyanatha S, Lan Q, Rothman N, Smith MT, Zhang L, Shen M, Li G, Yin S, Kim S, Rappaport SM. Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers. Environ Health Perspect. 2007 Jan;115(1):28-34. PMID: 17366815
[abstract]
Kim S, Vermeulen R, Waidyanatha S, Johnson BA, Lan Q, Smith MT, Zhang L, Li G, Shen M, Yin S, Rothman N, Rappaport SM. Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2246-52. PMID: 17119053
[abstract]
Vermeulen R, Lan Q, Li G, Rappaport SM, Kim S, van Wendel de Joode B, Shen M, Bohong X, Smith MT, Zhang L, Yin S, Rothman N. Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches. J Environ Monit. 2006 Nov;8(11):1143-8. PMID: 17075621
[abstract]
Shen M, Lan Q, Zhang L, Chanock S, Li G, Vermeulen R, Rappaport SM, Guo W, Hayes RB, Linet M, Yin S, Yeager M, Welch R, Forrest MS, Rothman N, Smith MT. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis. 2006 Oct;27(10):2083-9. PMID: 16728435
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