Environmental Health Scicnces School of Public Health University of California, Berkeley University of California, Berkeley
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EHS: assessing exposure and health impacts; protecting the community and workplace.
Luoping Zhang
Adjunct Professor
Luoping Zhang  
(510) 643-5189
(510) 642-0427
388 Li Ka-Shing Center

Mailing Address:
50 University Hall #7360
University of California, Berkeley
Berkeley, CA 94720-7360
Ph.D., Biochemical Toxicology, Simon Fraser University, 1993
M.S., Biochemistry, Huazhong University of Science and Technology, P.R. China, 1985
B.S. Physical Chemistry, Wuhan University, P.R. China, 1982

PH 270C Practical Toxicology (Sp) [description]

Research interests:
  • Mechanisms of bone marrow toxicity caused by benzene
  • Application of FISH as a biomarker in studies of childhood leukemia and other types of cancer
  • Application of gene expression profiling in molecular epidemiology and RNAi
Dr. Zhang has been working toward applying FISH to understand the mechanisms of bone marrow toxicity caused by benzene and as a biomarker for childhood leukeumia and other types of cancer. Recently, her research interest has turned to toxicogenomics, leading research efforts to apply gene expression profiling in molecular epidemiology and RNAi in human cell culture studies of chemical exposure.
Recent Publications
Ren X, Ji Z, Yuh J, Tang M, Bersonda J, Smith MT and Zhang L (2013). The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines. Arch Tox. 87(1):189-196. PMID: 22872141
Zhang L, Bassig BA, Mora JL, Vermeulen R, Ge Y, Curry JD, Hu W, Shen M, Qiu C, Ji Z, Reiss B, McHale CM, Liu S, Guo W, Purdue MP, Yue F, Li L, Smith MT, Huang H, Tang X, Rothman N, Lan Q (2013). Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene. Carcinogenesis. doi: 10.1093/carcin/bgs403 PMID: 232767951
Zhang L, Lan Q, Ji Z, Li G, Shen M, Vermeulen R, Guo W, Hubbard A, McHale CM, Rappaport SM, Hayes RB, Linet B, Yin S, Fraumeni JF, Rothman N, and Smith MT (2012). Leukemia-specific chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia, doi:10.1038/leu.2012.143. PMID: 22643707
McHale CM, Zhang L and Smith MT (2012). Current understanding of the mechanism of benzene-induced leukemia in humans: Implications for risk assessment Carcinogenesis, 33(2):240-52. PMID: 22166497
Duong A, Steinmaus C, McHale CM, Vaughan CP & Zhang L (2011). Reproductive and developmental toxicity of formaldehyde: a systematic review. Mutation Research Review. PMID: 21787879
Zhang L, Lan Q, Guo W, Hubbard AE, Li G, Rappaport SM, McHale CM, Shen M, Ji Z, Vermeulen R, Yin S, Rothman N and Smith MT (2011). Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene. Carcinogenesis, 32(4):605-612. PMID: 21216845
Ren X, McHale CM, Skibola CF, Smith AH, Smith MT and Zhang L (2011). An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ Health Perspect, 119(1):11-19. PMID: 20682481
Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT and Zhang L (2011). Involvement of N-6 Adenine-Specific DNA Methyltransferase 1 (N6AMT1) in Arsenic Biomethylation and Its Role in Arsenic-Induced Toxicity. Environ Health Perspect, 119(6):771-777. PMID: 21193388
McHale CM, Zhang L, Lan Q, Vermeulen R, Li G, Hubbard AE, Porter KE, Thomas R, Portier CJ, Shen M, Rappaport SM, Yin S, Smith MT and Rothman N (2011). Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect, 119(5):628-634. PMID: 21147609
McHale CM, Zhang L, Hubbard AE and Smith MT (2010). Toxicogenomic profiling of chemically exposed humans in risk assessment. Mutation Research, 705:172-183. PMID: 20382258
Zhang L, Tang X, Rothman N, Vermeulen R, Ji Z, Shen M, Qiu C, Guo W, Liu S, Reiss B, Freeman LB, Ge Y, Hubbard AE, Hua M, Blair A, Galvan N, Ruan X, Alter BP, Xin KX, Li S, Moore LE, Kim S, Xie Y, Hayes RB, Azuma M, Hauptmann M, Xiong J, Stewart P, Li L, Rappaport SM, Huang H, Fraumeni JF, Jr., Smith MT and Lan Q (2010). Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev, 19(1):80-8. PMID: 20056626
Zhang L, Steinmaus C, Eastmond DA, Xin XK and Smith MT (2009). Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res Rev, 681(2-3):150-168. PMID: 18674636